Since the mTOR pathway is a target for inhibition in cancer treatment, and some previous studies have reported a positive association of high levels of pS2448-mTOR with poor prognosis in breast cancer [21,29-32], the relationship we have found between p-S2448 mTOR and the P7-score reflecting good outcome in patients subsequently treated with adjuvant tamoxifen therapy, was unexpected. This evidence concerns the gene MTOR and cancer.