A serum IL-2 level greater than 4 pg/mL had a sensitivity of 90.9% and a specificity of 78.2% to rule out sepsis and intracranial infection (Youden index J: 0.6912); a serum IL-6 level equal to 8.5 pg/mL or lower had a sensitivity of 100.0% and a specificity of 71.0% to rule out sepsis and intracranial infection (Youden index J: 0.7104); a serum IL-10 level equal to 3.6 pg/mL or lower had a sensitivity of 90.9% and a specificity of 79.1% to rule out sepsis and intracranial infection (Youden index J: 0.7001). The gene discussed is IL6; the disease is Sepsis.