A serum IL-2 level greater than 4 pg/mL had a sensitivity of 90.9% and a specificity of 75.6% to rule out sepsis and intracranial infection; a serum IL-6 level equal to 8.5 pg/mL or lower had a sensitivity of 100.0% and a specificity of 73.3% to rule out sepsis and intracranial infection; a serum IL-10 level equal to 3.6 pg/mL or lower had a sensitivity of 90.9% and a specificity of 77.8% to rule out sepsis and intracranial infection, which showed similar power to rule out the possibility of sepsis and intracranial infection to that in the derivation cohort (Table 3). The gene discussed is IL10; the disease is Sepsis.