The AUCs for IL-2, IL-6, IL-10 and CRP were 0.901 (95% CI, 0.866 to 0.930), 0.86 (95% CI, 0.821 to 0.894), 0.888 (95% CI, 0.851 to 0.918) and 0.848 (95% CI, 0.807 to 0.883) respectively, indicating that IL-2, IL-6 and IL-10 were effective biomarkers to rule out sepsis and intracranial infection. This evidence concerns the gene IL6 and Sepsis.