The AUCs for IL-2, IL-6 and IL-10 were 0.901 (95% CI, 0.866 to 0.930), 0.860 (95% CI, 0.821 to 0.894), 0.888 (95% CI, 0.851 to 0.918), respectively, indicating that IL-2, IL-6 and IL-10 were effective biomarkers to rule out sepsis and intracranial infection. The gene discussed is IL6; the disease is Sepsis.