IL-4 did not elevated in patients with sepsis, but CRP and the inflammatory cytokine levels of IL-6, IL-10, TNF-α and IFN-γ significantly elevated when compared with the control group (median levels, mg/L: CRP: 10.0 vs. 2.0, P = 0.00; median levels, pg/mL: IL-6: 33.7 vs. 4.1, P = 0.00; IL-10: 6.9 vs. 2.4, P = 0.00; TNF-α: 2.5 vs. 2.3, P = 0.04; IFN-γ: 8.0 vs. 4.6, P = 0.00). Here, IL4 is linked to Sepsis.