TLR4 and neoplasm: Using semi-quantitative scoring, a positive relationship was noted between TLR4 staining score in the tumor stroma and tumor stage, controlling for histology grade, with significantly higher intensity score for stages 3 and 4 compared to stage 1 (Stage 1 = 2.80, Stage 2 = 3.24, Stage 3 = 4.36, Stage 4 = 3.75; p = NS, 0.0004, and 0.04, respectively) (Figure 4C,4D,4E).