The low Bcl2 transcriptional expression observed in association with higher protein MAT levels of Bcl-2 (as detected by immunohistochemistry and immunoblotting) in the ACD group could be explained by cytosine methylation, which greatly increases the stability of the Bcl2 promoter (as described by Lin et al. [39]). Here, BCL2 is linked to granular corneal dystrophy type II.