TP53 and breast cancer: In the neoadjuvant setting, cT3-4 breast cancer patients with a TP53-mutation had a higher likelihood of pathological complete remission (pCR) and an 80% six-years RFS after intensified cyclophosphamide-based chemotherapy, but only a 50% six-year RFS after FEC-docetaxel (FEC-D) [34,35].