In critical sepsis patients, BNP concentrations on day 1 were significantly higher in 28-day nonsurvivors than in survivors (1,099.5 pg/ml vs. 732.4 pg/ml; P = 0.049); however, BNP levels showed no significant differences from day 2 to day 5 (Figure 2, left panel). The gene discussed is NPPB; the disease is Sepsis.