Notably, this region is the hallmark of the cluster 1 of tumours of the METABRIC classification [7,45] and encompasses druggable genes belonging to the kinase family, such as TLK2 and the phosphatase PPM1D. A the second frequently amplified recurrent region was the ERBB2 region, which was amplified in 22% of cases, a higher rate than that observed in other T1 and small T2 IDCs [46,47]. This evidence concerns the gene PPM1D and neoplasm.