All 15 patients who switched from the non-IgE- to the IgE-associated form had an early onset of AD and had been first referred to our Clinics before the age of 2; in particular, 4 children switched between the first and second year of life, 6 patients between the second and third year, 4 between the fourth and the seventh, and the last one before the eighth year (Figure 1). Here, IGHE is linked to Alzheimer disease.