In the IgE-associated form, remission occurred earlier (Figure 2); in those patients without respiratory symptoms, AD was present in roughly 70% of children at 60 months of life and in less than 20% of patients at 120 months.Moreover, the geometric mean values of total IgE increased year by year in IgE-associated AD, whereas in the non-IgE-associated form the total IgE level remained constantly low over time (Figure 3). This evidence concerns the gene IGHE and Alzheimer disease.