Moreover AD, especially the early-onset kind, could represent the first step of the atopic march[10,11] and it is a major risk factor for the development of asthma; and patients with specific IgE antibodies to common environmental allergens present a higher risk for progressing in the atopic march to respiratory allergic diseases, such as rhinitis and asthma, than those without IgE sensitization. The gene discussed is IGHE; the disease is rhinitis.