IGHE and Alzheimer disease: reported the presence of many differences between non-IgE-associated and IgE-associated AD: in particular, data about the prevalence of the non-IgE-associated form in the pediatric age are conflicting, ranging from 18% in the paper of Kalinke et al.[16] who studied 22 children aged 1–5 years, to 45% observed in the paper of Cabon et al.[20] in 59 children aged 0–12 years.