IGHE and allergic respiratory disease: We observed that in patients with IgE-associated AD, total and sIgE levels grow steadily with age, for the development of respiratory and/or food allergies, whereas in the other form, total IgE remain low and stable over time (Figure 3 and Table 2).Furthermore, because the IgE-associated AD group was much larger, we attempted to define another clinical phenotype by correlating the presence of respiratory allergy with other possible/probable biomarkers.