ERBB2 and breast cancer: GDC-0941, a selective and potent PI3K inhibitor, was effective in preclinical models of trastuzumab-resistant breast cancer, where administration of GDC-0941 in combination with HER2-directed treatment (trastuzumab, pertuzumab, or lapatinib) inhibited in a synergistic fashion growth of breast cancer cells [74,75].