Regarding the correlations with clinical parameters in TSCC, while univariate analysis demonstrated that the mRNA expressions of both higher Cox-2 and lower CDH-1 were significantly correlated with lymph node metastasis, the multivariate analysis revealed that a lower CDH-1 mRNA expression level was the only independent predictor of lymph node metastasis in this cohort. Here, CDH1 is linked to metastatic malignant neoplasm in the lymph nodes.