CDH1 and metastatic malignant neoplasm in the lymph nodes: On the other hand, our result regarding CDH-1 is consistent with the previous immunohistochemical studies of oral SCC that reported a significant correlation between reduced E-cadherin expression and lymph node metastasis [57-60], but not with others that showed no correlation between them [61-63], although all of those studies lacked multivariate analysis.