Interestingly, using the same three bladder cancer cell lines and three different Cox-2 inhibitors (etodolac, celecoxib, and NS-398), Adhim et al. found that E-cadherin mRNA was enhanced in all three cell lines by at least two Cox-2 inhibitors in each cell line, although the fold of increase remained the highest in T24 cells [43]. This evidence concerns the gene PTGS2 and urinary bladder cancer.