To investigate established gene markers of cardiac hypertrophy, we analyzed myocardial mRNA expression of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), β-myosin heavy chain (β-MHC), and sarcoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA2a). This evidence concerns the gene NPPA and cardiac hypertrophy.