FH and myeloid sarcoma: In light of our published finding that the relative plasma levels of the variants of regulator fH alter in progressive MS [18], the Tyr402His polymorphic variants (minor allele frequency 0.3) were separately measured; remarkably, the relative staining of Tyr and His variants was markedly different between MS cases and controls, suggesting that there were qualitative differences in fH variant expression and/or deposition between cases and controls with more frequent cell-associated fH, and in particular the His402 variant, in MS.