The addition of IL-27 showed significant inhibition of the frequency of IL-17-producing CD4+ T cells in patients with active BD (25.8 ± 6.4 vs 10.6 ± 7.2; P = 0.002), patients with inactive BD (10.2 ± 2.3 vs 5.3 ± 2.3; P = 0.027) and healthy controls (9.6 ± 2.6 vs 5.6 ± 2.0; P = 0.026) (Figures 2C and 2E). This evidence concerns the gene IL27 and Behcet disease.