IL-27 levels were significantly lower in the serum from patients with active BD (955.5 ± 394.8 pg/ml) compared with patients with inactive BD (1,964.9 ± 1,885.8 pg/ml; P = 0.009) and healthy controls (2,608.9 ± 2,051.7 pg/ml; P < 0.001). The gene discussed is IL27; the disease is Behcet disease.