Exposure to rIL-27 led to significantly decreased IL-17 production by stimulated naïve CD4+T cells from patients with active BD (7,351.2 ± 1,110.6 vs 5,560.5 ± 1,647.5 pg/ml; P = 0.012), patients with inactive BD (4,875.1 ± 1,729.6 vs 2,722.5 ± 1,061.1 pg/ml; P = 0.047) and healthy controls (3,597.0 ± 1,089.2 vs 1,837.0 ± 684.5 pg/ml; P = 0.001). This evidence concerns the gene CD4 and Behcet disease.