Moreover, the SAC-treated PBMCs in patients with active BD still produced a lower level of IL-27 (816.8 ± 163.5 pg/ml) compared to levels in patients with inactive BD (1,355.4 ± 259.4 pg/ml; P = 0.019) and levels in healthy controls (1,408.7 ± 314.9 pg/ml; P = 0.010) (Figure 1C). This evidence concerns the gene IL27 and Behcet disease.