In breast cancer, the chemotactic and invasive activity of SDF-1α/CXCR4 is mediated by both Gα13-mediated activation of RhoA and Gαi-mediated activation of Rac1 via DOCK180/ELMO, which regulate cytoskeletal remodeling [5], [6]. This evidence concerns the gene CXCR4 and breast carcinoma.