Nevertheless, like in other diseases with evidence of a pathogenic role of the KIR3DL1/Bw4 interaction [32], it may also be relevant in BD to precisely determine the specific KIR3DL1 subtypes in order to detect mutual influences of NK cell receptors together with Bw4-80I on the pathogenesis of the disease. This evidence concerns the gene KLRD1 and Behcet disease.