Analysis of these Bw4 HLA-B allotypes in the B*51-negative BD patients revealed a significant association of BD with presence of Bw4-80I, but not of Bw4-80 T in the German groups (Bw4-80I P = 0.0007, Pc = 0.0042, OR = 2.35, 95% CI 1.41 to 3.93) (see Additional file 1: Table S4). Here, HLA-B is linked to Behcet disease.