Total body weight decreased significantly in all hyperglycemia groups; the reduction in body mass averaged 11 ± 2%, 13 ± 2% and 15 ± 1% for hyperglycemia, hyperglycemia + PEG-SOD and hyperglycemia + denatured PEG-SOD groups, respectively (P <0.001), when compared to control animals in which total body weight increased by 13 ± 4%. Here, SOD1 is linked to Hyperglycemia.