In pediatric acute lymphoblastic leukemia we identified three miRSNPs modulating the ALL risk, in ETV6, PML and TLX1. The tumor suppressor ETV6 (TEL) is a transcription factor (repressor of translation) with a crucial role in the embryonic development and hematopoietic regulation [38,39]. The gene discussed is ETV6; the disease is acute lymphoblastic leukemia.