In ALL risk genotypes were defined as ETV6_rs1573613 CC, PML_rs9479 GG, TLX1_rs2742038 TT, ATM_rs227091 CC and CT, and IRF8_rs10514611 TT (the latter two reached borderline significance in the analysis of individual SNPs). The gene discussed is TLX1; the disease is acute lymphoblastic leukemia.