IL1B and Hyperglycemia: Reduced H3K9 methylation was also observed at the IL-1β and TNF-α promoters in LPS-treated THP-1 cells [52,53], at the MMP-9 promoter in phorbol 12-myristate 13-acetate–treated HeLa cells [54] and at the NF-κB-p65 promoter in a model of transient hyperglycemia in bovine aortic endothelial cells [55].