It appears that NF-κB, master regulator of inflammation [114], has tissue-protective functions in the intestine as IEC-specific inhibition of NF-κB in mice through deletion of NEMO (also called IKKγ; IκB kinase-γ) [115], or both IKKα and IKKβ subunits spontaneously cause severe chronic intestinal inflammation [116,117,118]. The gene discussed is IKBKG; the disease is gastroenteritis.