AGO2 and plasma cell myeloma: To validate the pro-angiogenic functional role of AGO2 in MM, we used lentiviral transfection of an AGO2-shRNA to silence AGO2 expression in the H929 and LP-1 myeloma cell lines (H929-si-AGO2 and LP-1-si-AGO2) and also generated scramble controls (H929-si-NC and LP-1-si-NC; Additional file 1: Figure S1).