Accordingly, serum IgE values between N and 1.5 N were considered as low, between 1.5 N and 2 N as moderate IgE levels and above 2 N as the highest levels.As indicated in Figure 1, irrespective of helminth infection, individuals infected by malaria showed significantly high levels of serum IgE compared with malaria free apparently healthy controls (with and without helminth infections). This evidence concerns the gene IGHE and malaria.