To begin investigating the regulation of AAT under conditions of normal and limiting nutrient availability, the expression level and localization of three AAT proteins, LAT1, 4F2hc, and ASCT2, were determined in placenta samples from IUGR, PE and both full-term and maternal age-matched pre-term controls using immunohistochemistry (IHC). This evidence concerns the gene SERPINA1 and fetal growth restriction.