MMP2 and neoplasm: Recent data indicate that miR-29s have multiple functions via binding to the 3’UTR of the target mRNAs: regulation of methylation status in lung cancer via targeting DNA methyltransferases 3A and 3B [14]; suppression of tumor angiogenesis, invasion and metastasis by regulating MMP-2 expression [15]; regulation of the processing of the β-amyloid precursor protein by decreasing β-secretase expression [16]; and activation of p53 via suppressing p85 alpha and CDC42, which both negatively regulate p53 [17].