Areas under the ROC curves showed that plasma levels of Ang-2 and TM on day 1 had modest discriminative powers in development of AKI (0.833; 95% confidence interval, 0.737 to 0.928; P <0.001; and 0.796; 95% confidence interval, 0.681 to 0.911; P <0.001, respectively). This evidence concerns the gene ANGPT2 and acute kidney injury.