ACE and chronic kidney disease: In a placebo-controlled, double-blind trial 112 patients with stage 2 and 3 CKD with good blood pressure (BP) control on established treatment with ACE inhibitors or Angiotensin II Receptor Blockers (ARB) were treated in an active run-in phase with spironolactone 25 mg once daily and then randomised to continue spironolactone or to receive a matching placebo.