Since spironolactone is well recognised as an effective anti-hypertensive agent for patients with hypertension, even when this is resistant to other drugs [32], the intensive phenotyping of blood pressure, LV function, and arterial stiffness in the Benefits of Aldosterone Receptor Antagonism in Chronic Kidney Disease (BARACK D) trial will enable modelling of the extent to which any positive results may be explained by any BP differences between study arms. Here, NR3C2 is linked to hypertensive disorder.