IFNA1 and hepatocellular carcinoma: TLR7 and −9 agonists have great therapeutic potential against HCC because they induce the synthesis of the mediators of anti-viral and anticancer immunity such as IFN-α and IFN-γ-inducible protein 10 (IP-10), and induce a sustained increase in 2′5′-oligoadenylate synthesis [20].