Using this Registry, we have made important observations: all-site cancer accounted for 25% of diabetes-related deaths, led by hepatocellular and colorectal cancer; a 1% increase in HbA1c was associated with an 18% increased hazard ratio (HR) of all-site cancer after adjustment for confounders including drug use; use of insulin, sulphonylurea, metformin, thiazolidinedione (TZD), RAS inhibitors or statins was associated with reduced cancer risk; and there were non-linear risk associations between lipids and cancer [2]. The gene discussed is INS; the disease is diabetes mellitus.