Furthermore, we found that the up-regulation of HBXIP was significantly correlated with those of HBx (or survivin) in 22 human HCC tissues by quantitative real-time polymerase chain reaction (qRT-PCR) (r = 0.797 or 0.717, p <0.001, Pearson′s correlation, Figure 3D, E). Here, BIRC5 is linked to hepatocellular carcinoma.