Then, pyrrolidine dithiocarbamate (PDTC, 1 μg/10 μl from day 3 to day 15), an inhibitor of NF-κB, was daily delivered via intrathecal catheter to suppress the PAR2-NF-κB signaling in the rats with bone cancer pain. The gene discussed is NFKB1; the disease is bone neoplasm.