Considering that the plasmin-digested AMH has been reported to be more active in cultured human endometrial cell lines[15], human plasmin was used to cleave and activate the recombinant Human AMH at its monobasic arginine-serine site at residues 427-428 and then tested in functional experiments on both endometriosis stromal and epithelial cells. The gene discussed is AMH; the disease is endometriosis.