ESR1 and Anxiety: Upregulation of Dnmt3a mRNA in the male prefrontal cortex correlated with hypermethylation of the Esr1 gene; downregulation of Dnmt1 in the female hypothalamus associated with hypomethylation of the Esr1 gene; decreased Esr1 expression in the male prefrontal cortex and in the female hypothalamus; changes in social, exploratory and anxiety-like behavior.