GRM5 and Anxiety: Therefore, we wanted to ascertain that double transgenic expression of APPswe and PS1∆E9 does not alter changes in the locomotor (distance traveled), anxiety (centre time) and exploratory (number of rearing events) behaviours induced by mGluR5 deletion in twelve month old wild-type and APPswe/PS1∆E9 mice lacking mGluR5 expression over a 2 h period in an open field arena.