KCNA3 and atrial fibrillation: This is a sodium- and potassium-channel blocking agent, which effects all phases (0 – IV) of the atrial action potential (AP) and terminates AF by increasing the atrial effective refractory period (AERP) by blocking the potassium (IKur, IKACh, IKr and Ito) and sodium currents (INa) in a concentration-, rate- and voltage-dependent manner[25].