Because TREM2 serves as a phagocytic receptor of apoptotic neurons [18,24], and the efficient clearance of dead cells requires microtubule-associated protein 1 light chain 3A (LC3)-associated phagocytosis [25], we attempted to study the expression of LC3 in NHD brains by immunohistochemistry. Here, TREM2 is linked to Nasu-Hakola disease.