CD40LG and neoplasm: The performance of the 3 antigen panel for IgM was superior in the pre-diagnostic sera with an AUC of 0.841 (95% CI 0.7-0.966, p < 0.001) with a sensitivity of 0.7 and specificity of 0.9 as compared to tumor bearing sera, at 0.676 (95% CI 0.48-0.84, p = 0.141).