A combination of Otud6b, Stk39 and Lgals8 gave an AUC of 0.868 (95% CI 0.744-0.968, p < 0.001) for pre-diagnostic sera and 0.871 for sera derived from tumor bearing mice (95% CI 0.744-0.976, p < 0.001) with a sensitivity of 0.75 and specificity of 0.8. The gene discussed is STK39; the disease is neoplasm.