In addition, the proposed study seeks to investigate individual differences in training outcome and its relation to dementia biomarkers such as tau, phospho-tau, and β-amyloid proteins as well as candidate genes such as APOE and LMX1A. A recent study by Bellander et al. [35] indicates that certain combinations of the different alleles of the LMX1A gene might predict those healthy adults most likely to benefit from WM training. This evidence concerns the gene LMX1A and dementia.