We found rs11216153 polymorphism of ApoA1 was associated with ALI, the GG genotype and G allele was common in the ALI patients (76.9%, 88.1%, respectively) than both in the control subjects (55.8%, 75.8%, respectively, P < 0.001) and in the sepsis alone patients (58.2%, 78.4%, respectively, P < 0.001). This evidence concerns the gene APOA1 and Sepsis.