CEACAM5 and neoplasm: However, multivariate regression analysis of the prognostic factors showed that a preoperative serum CEA level ≥100 ng/mL (P = 0.0001, hazard ratio (HR) = 2.06) and four or more tumor nodules (P = 0.041, HR = 1.53) were independent prognostic factors of CRC recurrence following LR for hepatic metastasis.