DCLK1 and colonic neoplasm: Moreover, it was previously reported that U0126 suppresses upregulation of DCLK1 in response to NGF stimulation in PC12 cells[25] and a search of the NCBI gene expression omnibus database produced multiple datasets demonstrating significant DCLK1 downregulation following U0126 inhibition in colon cancer cell lines (Figure 4D & Additional file1: Figure S2F)[26,27].