LGR5 and BMI1 are stem-cell markers coexpressed with DCLK1 in the intestine[28,29], regulated downstream of DCLK1 following radiation injury in intestinal epithelial DCLK1 knockout mice[30], and markers of populations of cells with tumor stem cell activity in intestinal adenomas[31] and pancreatic adenocarcinoma[32]. This evidence concerns the gene LGR5 and neoplasm.