DCLK1 is overexpressed in tumors and pancreatic intraepithelial (PanIN) lesions of P48CreKrasLSLG12D, Pdx1Cre; KrasLSLG12D, Pdx1Cre; KrasLSLG12D; Tp53Flox/+ and Mist1CreER; KrasLSLG12D pancreatic cancer mice as well as surgical resection specimens of human pancreatic ductal adenocarcinoma (PDAC) patients, and is significantly correlated to PanIN lesion stage[8,9]. The gene discussed is DCLK1; the disease is familial pancreatic carcinoma.