Down-regulated genes involved in cell transport included several solute carrier family members (SLC7A9, SLC26A3, SLC15A1, SLC13A1 and SLC6A4), CUBN (encoding cubilin, a transporter of cobalamin) and S100G, a gene encoding a calcium transporter, which was down-regulated more than 22-fold at time of peak infection (14 dpc) compared to uninfected pigs. The gene discussed is CUBN; the disease is infection.