CD8A and chronic obstructive pulmonary disease: There was a significant increase in the percentage of CD8+ NKT-like cells in patients with COPD compared with control subjects (59 ± 8 and 35 ± 6% (mean ± SD) for COPD patients and control groups respectively).There was a significant increase in the percentage of CD28null/CD8+ NKT-like cells in patients with COPD compared with control subjects (Figure 1) but no significant change for CD28null/CD8- NKT-like cells between groups (p > 0.05).