However, a recent study investigated the relationship between HRT use and MSI, BRAF and CIMP status of the tumours [15], whereby HRT (ever vs never use) was inversely associated with overall CRC risk, lower risk for MSI-L/MSS tumours and borderline significantly lower risks for CIMP-negative and BRAF-wildtype tumours, suggesting that HRT may have more pronounced inhibitory effects on the”traditional” pathway, as compared to the serrated or alternate pathways, of colorectal carcinogenesis. This evidence concerns the gene BRAF and neoplasm.