However, a recent study investigated the relationship between HRT use and MSI, BRAF and CIMP status of the tumours [15], whereby HRT (ever vs never use) was inversely associated with overall CRC risk, lower risk for MSI-L/MSS tumours and borderline significantly lower risks for CIMP-negative and BRAF-wildtype tumours, suggesting that HRT may have more pronounced inhibitory effects on the”traditional” pathway, as compared to the serrated or alternate pathways, of colorectal carcinogenesis. The gene discussed is BRAF; the disease is colorectal carcinoma.