As a result, a number of differentially expressed serum proteins involved in inflammation mediated acute phase response (alpha-1-acid glycoprotein, leucine-rich-alpha-2-glycoprotein, haptoglobin, hemopexin, serotransferrin, alpha-2-HS-glycoprotein, albumin), complement and coagulation cascades (AT III, CLU, C3, alpha-2-antiplasmin), apolipoproteins (apoA-I and apoA-IV) and vitamin D metabolism pathway were identified in dogs with babesiosis. This evidence concerns the gene CLU and babesiosis.