Especially, HOXB9 induced tumor proliferation and metastasis by activating angiogenesis [5], but little is known about the relationship between HOXB9 expression and angiogenesis in colorectal cancer, which is widely treated by anti-angiogenic therapy in combination with chemotherapy, and about the impact of anti-angiogenic treatment on tumors with angiogenic properties. Here, HOXB9 is linked to colorectal cancer.