The weakly invasive head and neck squamous cell carcinoma (HNSCC) cell line HN-4 and human breast cancer cell line MCF-7 exhibited a characteristic epithelial cobblestone-like morphology with high expression of the epithelial marker E-cadherin and low expression of the mesenchymal marker Vimentin. The gene discussed is VIM; the disease is head and neck squamous cell carcinoma.