Though other MMPs (e.g., MMP-1, -2, -8, -9, -13) have been linked to degradation of laminin, vitronectin, fibronectin, enactin, collagen I-IV, MMP-10 has been identified as a stromelysin which can degrade various proteoglycan components of the ECM [23], thus facilitating tumor cell dissociation. The gene discussed is LAMB2; the disease is neoplasm.