BRAF and neoplasm: Moreover, while BRAF mutations were equally distributed among discrepant multiple melanomas (47.5% wild-type first tumors and mutated subsequent tumors, 47.5% mutated first tumor and wild-type subsequent tumors), rates of cKIT and CyclinD1 amplification were found to significantly increase moving from incident to subsequent primary melanomas (p values, <0.001 and 0.002, respectively).