Nevertheless, progression of disease in patients with such discrepancies in primary melanomas may suggest taking into consideration all developing metastases for BRAF mutation analysis cucaccording to the recent indications provided by the National Comprehensive Cancer Network (NCCN; at http://www.nccn.org/professionals/physician_gls/f_guidelines.asp) guidelines, most recent melanoma tissue samples should be considered as adequate for BRAF mutation screening]. The gene discussed is BRAF; the disease is melanoma.