It has been reported that melanomas on skin not chronically exposed to sun usually carry a mutated BRAF whereas those arising from chronically sun-damaged (CSD) skin infrequently have BRAF mutations but present an increased copy number of the proliferation-controlling CyclinD1 (CCND1) or cKIT genes, with subsequent increased expression of the correspondent proteins [25-28]. The gene discussed is CCND1; the disease is melanoma.