Additionally, T1D patients presented several genes that were differentially expressed compared to T2D patients, including immune response genes, as MHC region genes (HLA-DQA1 and DQA2), clusters of differentiation genes (CD8B, CD55, CD83), cytokines (IL1A, IL1B,IL6, IL8, IL23A), chemokines (CXCL1, CCL3L3, CXCL2, CXCL3, CCL20, CCL23, CCL24, CCL3, CCL4), NOD-like receptor signaling pathway (CXCL1, IL6, CARD9, TNF, IL8, CXCL2, CASP8, NFKBIA, IL1B, MAPK8, TNFAIP3, NLRP3) and transcription factors (GLIS2, SOX8, FOXC2, FOXC1, FOXE1, FOXK1). The gene discussed is GLIS2; the disease is type 2 diabetes mellitus.