Additionally, T1D patients presented several genes that were differentially expressed compared to T2D patients, including immune response genes, as MHC region genes (HLA-DQA1 and DQA2), clusters of differentiation genes (CD8B, CD55, CD83), cytokines (IL1A, IL1B,IL6, IL8, IL23A), chemokines (CXCL1, CCL3L3, CXCL2, CXCL3, CCL20, CCL23, CCL24, CCL3, CCL4), NOD-like receptor signaling pathway (CXCL1, IL6, CARD9, TNF, IL8, CXCL2, CASP8, NFKBIA, IL1B, MAPK8, TNFAIP3, NLRP3) and transcription factors (GLIS2, SOX8, FOXC2, FOXC1, FOXE1, FOXK1). Here, MAPK8 is linked to type 1 diabetes mellitus.