Additionally, T1D patients presented several genes that were differentially expressed compared to T2D patients, including immune response genes, as MHC region genes (HLA-DQA1 and DQA2), clusters of differentiation genes (CD8B, CD55, CD83), cytokines (IL1A, IL1B,IL6, IL8, IL23A), chemokines (CXCL1, CCL3L3, CXCL2, CXCL3, CCL20, CCL23, CCL24, CCL3, CCL4), NOD-like receptor signaling pathway (CXCL1, IL6, CARD9, TNF, IL8, CXCL2, CASP8, NFKBIA, IL1B, MAPK8, TNFAIP3, NLRP3) and transcription factors (GLIS2, SOX8, FOXC2, FOXC1, FOXE1, FOXK1). This evidence concerns the gene CASP8 and type 2 diabetes mellitus.