These results indicate that miR-130a facilitates HeLa and C33A cell viability and growth, which is consistent with NF-κB’s effects on HeLa and C33A cells.As miR-130a and NF-κB plays the same role on the growth of cancer cells, which prompt us miR-130a maybe one of the regulatory mechanisms of NF-κB, in order to verify this, we performed an experiment using by NF-κB in cells with miR-130a knockdown. This evidence concerns the gene NFKB1 and cancer.