Since the MMP family proteins are well known to be involved in tumor metastasis, we tested if they could be regulated through hnRNP K. We used Affymetrix cDNA microarrays to compare the expression profiles of MMP family genes in NPC-TW02 cells transiently transfected with hnRNP K-targeting siRNA versus those transfected with negative control siRNA, and in NPC tissue samples and adjacent normal tissues. This evidence concerns the gene HNRNPK and nasopharyngeal carcinoma.